#  DF/HCC Seminars in Oncology Series with Stefani Spranger 

 



####  calendar\_today Date and Time 

 **December 19, 2017** 

 12:00PM - 01:00PM EST 

####  pin\_drop Location 

 **Yawkey 308**  



 

 



 

 **Stefani Spranger, Ph.D.**  
Assistant Professor of Biology, Koch Institute for Integrative Cancer Research at MIT

 "The goal of the Spranger lab is to understand how a range of tumor cell-intrinsic, tissue-specific and environmental factors directly impact the interaction between the cancer and the immune system. Cancer immunotherapies, first and foremost checkpoint blockade therapy (anti-CTLA4 and anti-PD-1/PD-L1), have revolutionized cancer treatment. Despite these advances only a fraction of cancer patients responds to immunotherapeutic interventions. Even for cancer types that typically show high response rates, only a fraction of patients respond. We aim to understand which tumor cell-intrinsic, tissue-macroenvironmental and environmental factors mediate resistance mechanisms against immunotherapy by affecting T cell infiltration into tumors."



 

 



 

 

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