#  Single Cell and Spatial Technologies  

 



 **Semester:** Spring

 **Offered:** 2021

 **Course Description and Assignments**

 Single cell and spatial technologies allowed us to surpass granularity and context barriers, revolutionizing cancer research. They permit the investigation of cellular transcriptional programs, tumor clonal evolution, or immune cell receptors in unparalleled resolution, while spatial methods enable the fine-grained characterization of the tumor microenvironment and cell-cell communication *in situ*.   
  
In this course we will focus on existing and upcoming technologies and how they can shape the scope of basic and translational cancer research. We will start with a general introduction to the methods, their capabilities, and shortcomings, and then proceed to discuss cutting-edge applications and still open research questions.

 Each session will also incorporate walkthroughs of analyses, experiments, and recent publications, as well as 30’ of interactive discussion.

 Registered participants will formulate a one-page example of a cancer research application using these technologies.  
  
**Course Director & Instructor**  
Ioannis Vlachos, PhD, co-Director of the Bioinformatics Program, Cancer Research Institute, Beth Israel Deaconess Medical Center / Director of Bioinformatics, Precision RNA Medicine Core, HMS Initiative for RNA Medicine / Broad Institute of MIT and Harvard  
  
**Guest Lecturer**  
Yered Pita-Juarez, PhD, Postdoctoral Research Fellow, Beth Israel Deaconess Medical Center / Harvard Medical School / Broad Institute of MIT and Harvard.   
  
More information about the course and registration can be found [here](https://curriculumfellows.hms.harvard.edu/classes/single-cell-and-spatial-technologies).