DF/HCC Seminars in Oncology Series - Jose Conejo-Garcia

Jose Conejo-Garcia, M.D., Ph.D.
Chair, Department of Immunology, Moffitt Cancer Center and Research Institute, Tampa, FL

"Dr. Conejo-Garcia’s research aims to understand and target mechanisms of immunosuppression in gynecologic malignancies. His recent work focuses on the biology of dendritic cells and how these cells are altered by tumors so they can evade the immune system by impairing antigen presentation. His recent research in ovarian cancer has also found that T cells redirected to molecules selectively expressed in ovarian cells can lead to tumor cell death and block disease progression without significant toxicity. Dr. Conejo-Garcia is also studying the role of commensal microorganisms in the orchestration of antitumor immune responses as well as novel checkpoint inhibitory receptor–ligand pairs that blunt protective immunity. "