NANOCOURSE - Cancer Metabolism: The Metabolomics Perspective

Date and Time

October 19, 2022
09:00AM - 03:00PM EDT

Location

Countway L02-025

THIS IS A THREE SESSION NANOCOURSE, OPEN ONLY TO PARTICIPANTS WHO REGISTER! FOR MORE INFORMATION ABOUT THE COURSE AND HOW TO REGISTER VISIT HERE

SESSION TWO

Day two will focus on LC-MS data analysis and statistics. Targeted and untargeted metabolomics platforms will be compared. Participants will work on analyzing metabolomics data using R-code and MetaboAnalyst.

Participants will:

  • Be introduced to theory and practice of data analysis, chromatography peaks alignment, ion adducts, and isotopes.
  • Be introduced to TraceFinder (TF) and Compound Discoverer (CD) and targeted vs untargeted LC-MS analysis
  • Practice data analysis using TF and CD.
  • Demo and practice data integration and statistics using R-code and MetaboAnalyst
  • Demo and practice preparation of data for publication using Prism and Illustrator
  • Participants will be given homework assignment: Data analysis, interpretation, visualization – communicate your results by preparing a short presentation. Group can present together.

Tentative Schedule

Time

Task

Notes

9-10pm

LC-MS data analysis intro

Discussion of targeted vs untargeted LC-MS analysis

Introduction into peak quality and alignment

10-12pm

Data analysis set up

TF and CD will be run remotely. TF for targeted CD for untargeted

12-13:30 pm

Lunch

CD analysis will continue unsupervised over lunch

13:30-3pm

Finalize data analysis. Export data, analyze with R-code, Metaboanalyst and Prism

These steps will be on personal computers

Participants can communicate via email to finalize analysis and presentations.