The primary goal of the research program in the Tothova laboratory is to contribute to our understanding of the biology of benign and malignant hematologic disorders, with a specific focus on the study of mechanisms of leukemogenesis in myelodysplastic...
Gut microbiota – the trillions of bacteria, fungi, viruses, and archaea that reside in our gut – contain a dynamic arsenal of products that can protect from or contribute to disease. Diet, medication, exercise, and disease impact the composition of the...
The focus of my research is to understand mechanisms of sensitivity and resistance to kinase inhibitors and to translate laboratory based observations into therapeutic treatments for patients with cancer. To achieve this goal we have taken a multifaceted...
Recurrence of cancer in the form of metastatic disease accounts for more than 90% of cancer patient deaths; however, tumor metastasis is considered an inefficient process and disseminated tumor cells can remain indolent for long periods of time...
The focus of our lab is to understand how small collections of genes, operating at local length scales, can establish order at long range distances to create overall cell shape, make the cell divide, segregate cargo within the cell, and create spatial...
The interdisciplinary research in the Shalek Lab aims to create and implement new approaches to elucidate cellular and molecular features that inform tissue-level function and dysfunction across the spectrum of human health and disease. This encompasses...
Stuart Schreiber's lab has reported on a number of small-molecule-based advances, including:
- co-discovering (also: Sol Snyder and David Sabatini) the protein kinase mTOR and illuminating intracellular signaling by mTOR and the protein phosphatase...
My laboratory focuses on uncovering knowledge gaps on the interactions between the immune system and cancer and defining immunotherapies that are effective against a broad range of tumors. To do so, we study various immune cells, including cytotoxic T...
