Complete Listing
Frederick W. Alt
alt@enders.tch.harvard.eduCharles A. Janeway Professor of Pediatrics
The broad focus of the Alt lab is the elucidation of mechanisms that generate antigen receptor diversity in the Immune system and mechanisms that maintain genomic stability in mammalian cells. Over the past decade we have developed remarkably sensitive...
Gad Getz
gadgetz@broadinstitute.orgProfessor of Pathology
Gad Getz directs the Cancer Genome Computational Analysis group at the Broad Institute of MIT and Harvard, where he is an institute member. Under Getz's leadership, the Cancer Genome Analysis group has established itself as a world leader in the...
Humsa Venkatesh
hvenkatesh@bwh.harvard.eduAssistant Professor of Neurology
Overview: Our lab studies the reciprocal interactions between the central nervous system and brain cancers. Our work emphasizes the electrical components of glioma pathophysiology and highlights the extent to which the brain and its neurons can control...
J. Wade Harper
wade_harper@hms.harvard.eduBert and Natalie Vallee Professor of Molecular Pathology
Ubiquitin and ubiquitin-like (UBL) protein conjugation systems control a vast array of cellular processes, and impact virtually every biological system. In this process, UBLs are activated through an activation and conjugation cascade before attachment to...
James A. DeCaprio
james_decaprio@dfci.harvard.eduProfessor of Medicine
The role of Merkel cell polyomavirus in Merkel cell carcinoma Merkel cell carcinoma is a skin cancer with a high rate of mortality. Factors that increase the risk for developing MCC include excessive exposure to sunlight, advanced age and an...
James Francis Gusella
gusella@helix.mgh.harvard.eduBullard Professor of Neurogenetics in the Department of Genetics
My laboratory is focused on understanding nervous system disease using molecular genetic strategies, beginning with human patients and proceeding through in vitro and modeling studies, with the ultimate goal of improving diagnosis, management and...
Joan S. Brugge
joan_brugge@hms.harvard.eduLouise Foote Pfeiffer Professor of Cell Biology
We are interested in elucidating the cellular processes and pathways that are involved in the initiation and progression of epithelial tumors. Currently, most of our studies involve investigations relating to breast cancer; however we have recently...
Jonathan C. Kagan
jonathan.kagan@childrens.harvard.eduMarian R. Neutra, PhD Professor of Pediatrics
Ancient signaling pathways lie at the base of the initiation of immunity, serving to transmit signals from Pattern Recognition Receptors (PRRs) to trigger the activation of anti-microbial defenses. All PRRs, which evolved to detect potentially pathogenic...
Kai Wucherpfennig
kai_wucherpfennig@dfci.harvard.edu; Wucherpfennig_lab@dfci.harvard.eduChair, Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute
Professor of Immunology
We study the molecular pathways that regulate T cell function in the tumor microenvironment, with an emphasis on developing novel mechanistic insights that lead to the development of the next generation of cancer immunotherapies. We integrate analysis of...
Karen Marie Cichowski
kcichowski@bwh.harvard.eduProfessor of Medicine
The focus of my laboratory is to elucidate how deregulated cell signaling drives cancer. To achieve this we have been taking a multi-faceted approach; combining mouse modeling techniques with basic biochemical and cell biological studies. One of the most...
Kevin M. Haigis
kevin_haigis@dfci.harvard.eduProfessor of Medicine
Our laboratory studies diseases of the gastrointestinal tract, with emphasis on colorectal cancer (CRC) and inflammatory bowel disease (IBD). We use both conventional and systems biology approaches to integrate studies of genetically engineered mouse...
Kevin Struhl
kevin@hms.harvard.eduDavid Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacology
Transcriptional regulation in response to environmental and developmental cues is mediated by the combinatorial and synergistic action of specific DNA-binding activators and repressors on components of the general transcription machinery and chromatin...
Kimberly Stegmaier
Kimberly_Stegmaier@dfci.harvard.eduProfessor of Pediatrics
My research program focuses on the integration of "omic" approaches for the identification of new protein targets and small-molecule modulators of malignancy with an eye toward clinical translation. Cancer discovery efforts in my laboratory have focused...
Kornelia Polyak
kornelia_polyak@dfci.harvard.eduProfessor of Medicine
Our goal is to identify differences between normal and cancerous breast tissue, determine their consequences, and use this information to improve the clinical management of breast cancer patients. The three main areas of our interests are: (1) how to...
Kristin White
kristin.white@cbrc2.mgh.harvard.eduAssociate Professor of Dermatology
Apoptosis is a prevalent and important cell fate during development and homeostasis of multicellular organisms. The long-term goal of our research is to understand the regulation and execution of apoptosis, using the powerful genetic and molecular...
Leonard Ira Zon
zon@enders.tch.harvard.eduProfessor of Stem Cell and Regenerative Biology
The laboratory focuses on the developmental biology of hematopoiesis and cancer. We have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. We also have undertaken chemical...
Loren David Walensky
loren_walensky@dfci.harvard.eduProfessor of Pediatrics
The Walensky laboratory focuses on the chemical biology of deregulated apoptotic and transcriptional pathways in cancer. Our goal is to develop an arsenal of new compounds-a “chemical toolbox”-to investigate and block protein interactions that cause...
Marc Vidal
marc_vidal@dfci.harvard.eduProfessor of Genetics
Within cells macromolecules form complex intertwined networks of functionally interacting components. The molecular mechanisms underlying biological processes correspond to particular steady states adopted by such cellular networks. Systems-level...
Marcia C. Haigis
marcia_haigis@hms.harvard.eduProfessor of Cell Biology
Our laboratory focuses on understanding the role that mitochondria play in mammalian aging and disease. Mitochondria are dynamic organelles that provide cells with energy even during dramatic changes in diet, stress and development. Mitochondria are also...
Mario L. Suvà
Suva.Mario@mgh.harvard.eduAssociate Professor of Pathology
My laboratory is focused on the biology of brain tumors, in particular glioblastoma and oligodendroglioma. My group is dissecting how cellular heterogeneity and plasticity contribute to tumor cell properties. We study primary human samples up to single...
